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Purity
99.4%
HPLC Tested
Ms verified
Coa included
LL-37
$149.95
Half-life
~1 hour
Purity
99.4
Mw
4493.3 g/mol
In stock
LL-37 is the active 37-amino-acid form of the human cathelicidin antimicrobial peptide (hCAP18). It is a cationic, amphipathic α-helical peptide produced by neutrophils, epithelial cells, and other immune cells. It serves as a key component of the innate immune system, providing broad-spectrum defense against bacteria, viruses, fungi, and parasites while also modulating inflammation and promoting tissue repair.
Mechanism of action
LL-37 exerts its effects primarily through membrane disruption: its amphipathic structure allows it to insert into negatively charged microbial membranes, forming pores or causing carpet-like destabilization that leads to leakage and cell death. Beyond direct antimicrobial activity, it modulates immune responses by interacting with receptors (e.g., TLRs, FPRL1), inhibiting pro-inflammatory cytokine release in some contexts while promoting chemotaxis and angiogenesis. It also enhances wound healing by stimulating cell migration, proliferation, and extracellular matrix remodeling.
Compound Profile
- Category Immunity and Defense
- Molecular weight 4493.3 g/mol
- Half-life ~1 hour
- Minimum purity 99.4
- Form Lyophilized powder
- Solvent Bacteriostatic water (BAC)
Storage
Critical Storage
Lyophilized: −20°C, stable 24 months. Post-reconstitution: 4°C, use within 30 days. Protect from light.
Reconstitution
Add 1–2 mL bacteriostatic water slowly along the vial wall. Gently swirl — do not shake. Allow 5–10 min for complete dissolution.
Quality Assurance & COA
HPLC Analysis
Identity + purity
Mass Spectrometry
Identity + purity
Sterility Testing
USP <71> compliant
Certificate of Analysis
Full COA ships with every order including HPLC trace, mass spec, and per-batch purity percentage.
Certifications
- Dual Third-Party Lab Tested
- HPLC Purity Verified
- Mass Spec Identity Confirmed
- Cold-Chain Certified Shipping
